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Subsequently, the NOAEL is corrected for difference in absorption between dermal dating remington arme de foc oral route in the rat, and for difference in dermal absorption in rat versus dermal absorption in human, according to example B5 of Chapter R8 of the Guidance on information requirements and chemical safety assessment.
According to the available study on percutaneous absorption of one of the main constituents of 1,4 -benzenediamine, N,N'-mixed Ph and tolyl derivs. According to two available studies on metabolism and excretion of two different main constituents of 1,4 -benzenediamine, N,N'-mixed Ph and tolyl derivs Jeffcoat, and Jeffcoat,the mean value for absobtion of the by the rats ingested test substances is Due to the clear structural similarities between the main constituents of 1,4 -benzenediamine, N,N'-mixed Ph and tolyl derivs.
No test data are available regarding absorption of 1,4 -benzenediamine, N,N'-mixed Ph and tolyl derivs. Assessment factors applied: Allometric scaling factors: 4 for rat vs.
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Subsequently, the NOAEL is corrected according to the default physiological parameters under the allometric scaling prinicple, as described in table R. As oral absorption by rat and human are assumed to be equal, no further corrections of the NOAEL value are required.
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